Significant Magnesium Deficiency in Depression

Magnesium levels were tested in a total of 457 patients suffering either chronic primary depression or chronic pain with depression. The magnesium load or tolerance test is considerably more reliable than serum, red blood cell, whole blood, or white blood cell magnesium levels. Virtually all significantly depressed patients are deficient in magnesium. Clinicians should consider the potential of therapeutic benefit from magnesium replacement therapy in chronic depression. Although magnesium deficiency has been reported in depression, this association is not widely recognized (1).